January 13: A heavily armed group violently storms the home of human rights defender Rogelia González Luis.

January 26: journalist Jose Ignacio Santiago Martinez is shot at in the Mixteca region.

January 26: Mexican Network of People Affected by Mining (REMA) publishes the statement “SEMARNAT Fails To Comply With Environmental Protection Mandate and Precautionary Principle, Putting Communities Of Los Valles De Ocotlán, Oaxaca at Deliberate Risk.”

February 3: Oaxaca concentrates the highest number of deaths of indigenous people and children since the beginning of the pandemic.

February 9: the former commissioner of the Oaxaca State Police, Froylan Carlos Cruz, is arrested and sent to informal preventive detention for his participation in the repression of a blockade in Nochixtlan in 2016.

February 10: Journalist Heber Lopez Vasquez is murdered in Salina Cruz.

February 16: The Ministry of the Interior conducts regional dialogues with journalists, human rights defenders, and civil society organizations to promote the General Law for the Protection of Human Rights Defenders and Journalists.

February 17: Relatives of Heber Lopez Vasquez call on the Federal Protection Mechanism for Human Rights Defenders and Journalists to provide them with better security conditions.

March 2: the No to Mining for a Future of All Front symbolically takes over the offices of the Ministry of Environment and Natural Resources (SEMARNAT) to protest against the imposition of the Cuzcatlan mining company.

March 13: Residents of Paso de la Reina carry out a day of intercultural dialogues throughout the territory in memory of those who lost their lives in the defense of the Rio Verde.

March 14: The Council of Autonomous Oaxacan Organizations (COOA) announces Day of Protest to demand release of Human Rights defender Fredy Garcia.

March 17: communities and civil organizations present the “San Jose Mining Project Report – On Violation of Human Rights in Communities of Ocotlan, Ejutla and Tlacolula of the Central Valleys in Oaxaca”.

April 6: journalists protest to demand justice for the murders of journalists Heber Lopez and Gustavo Sanchez, during the dialogue held by the Mechanism for the Protection of Human Rights Defenders and Journalists.

April 25: Camp of displaced Triqui people in Mexico City is evicted violently.

May 23: the defender of Afro-Mexican territory and campesino leader of the Democratic Civic Union of Neighborhoods, Colonies and Communities (UCIDEBACC), Humberto Valdovinos Fuentes, is murdered.

May 28: More than 100 armed people raid the Zapotec community of El Rebollero, shooting and burning homes.

June 1: the Federal Electricity Commission (CFE) cancels the electricity supply contract it had with the French semi-state Electricite de France (Electricity of France, EDF).

June 5: the Regeneration Movement (MORENA) party comes to power in Oaxaca for the first time in history.

June 27: Residents of Puente Madera denounce criminalization by the municipal government; they demand a halt to the militarization of the Isthmus.

June 30: The state of Oaxaca registers a total of 62 violent deaths of women so far this year.

July 4: Continuation of Gunna Sicaru (EDF) Wind Farm is denounced

July 11: Código DH launches the campaign against stigmatization and disqualification of the defense of human rights, “Defend: We all defend”.

July 19: Attacks on Community Leader David Hernandez in Puente Madera are denounced.

August 4: In a weekend there are at least 12 murders in different regions of the state. There are protests over violence in the framework of the La Guelaguetza festival.

August 8: The Triqui Unification and Struggle Movement (MULT) denounced that a group of armed people fired at the car in which its members were mobilizing

August 10: 16 Ben’za (Zapotec) communities of the Ocotlán-Zimatlán Valley receive their titles of “Indigenous Community Water Concession” after 16 years of struggle.

August 14: With the planting of trees, relatives, organizations and national and international groups begin a day of activities to demand the freedom of forest defender Pablo López Alavés.

August 17: members of the Marea Verde Mixteca create the collective Crecer sin Violencia that seeks to prevent serious violence against children due to the high number of reports of child sexual abuse in the region.

August 19: a few hours after being detained by elements of the municipal police, Abigail Hay Urrutia, is found dead inside the Salina Cruz jail cell.

September 5: Magistrate of the Unitary Agrarian Court of Tuxtepec rules in favor of the community of Unión Hidalgo against the company Desarrollos Eólicas Mexicanos S. A. de C. V.

September 7: After some 15 years of struggle, the General Assembly of the San Bartolo Coyotepec community and its inhabitants manage to close the wells that since 2002 had been concessioned to a soft drinks company.

September 7: the last four persons implicated in the murder of human rights defenders Alberta Honey Trujillo and Jyri Antero Jaakkola are released.

September 15: Feminist collectives and networks denounce the harassment of Lucero Rivero Ortiz for demanding clarification of the murder of her partner Humberto Baldovino Fuentes.

September 15: members of the Democratic Civic Union of Neighborhoods, Colonies and Communities are attacked with firearms.

October 24: provocations and attempted privatization of the Lands of Common Use in the Pitayal are denounced.

October 26: Filogonio Martinez Merino, former municipal agent of Paso de la Reina and defender of Río Verde is murdered.

October 31: Agrarian conflict between the municipalities of San Miguel Tiltepec and La Luz leaves two people dead. They demand a solution.

December 7: Lizbeth Victoria Huerta, former mayor of Asuncion Nochixtlan, and three other people also linked to the municipality are found guilty of the crime of forced disappearance; this is due to the case of the activist Claudia Uruchurtu Cruz, who disappeared in March 2021 after participating in a protest against the then mayor.